• NATURAL INHIBITORS OF THE EXPRESSION OF THE BACTERIAL HrpA1 GENE OF PSEUDOMONAS SYRINGAE PV. ACTINIDIAE

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Patent Information

Patent Owners

Università degli Studi di Verona

Regione Veneto

Priority Number

Priority Date

Patent Status

License

TRL

4

Funding Needs

€ 50K - 200K

Keywords

Pesticides, Plant diseases, Antibacterial

Research Team | Inventors

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NATURAL INHIBITORS OF THE EXPRESSION OF THE BACTERIAL HrpA1 GENE OF PSEUDOMONAS SYRINGAE PV. ACTINIDIAE

New Drugs & Therapies

Introduction

The invention concerns the field of antibacterial drugs and more specifically molecules that can inhibit the expression of crucial virulence genes of phytopathogenic bacteria. The invention aims to propose compounds and methods to combat plant diseases, in particular the bacterium Pseudomonas syringae pv. actinidiae in plants, more specifically in kiwi plants, that do not use copper or antibiotics. This invention also paves the way for the possible use of these molecules in innovative formulations of pesticides to inhibit bacterial virulence.

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Technical Features

Several bacterial species belonging to the Pseudomonas spp. they can cause diseases in plants of different families, from vegetables to fruit trees to ornamental plants. Means of control include the use of copper compounds, biocontrol agents and other plant defense biostimulants, but none of these methods solve the problem. The invention aims to propose compounds and methods to combat plant diseases, in particular the bacterium Pseudomonas syringae pv. actinidiae in plants, more specifically in kiwi plants, which overcome the aforementioned drawbacks and which in particular do not use copper or antibiotics. The aim is achieved by a series of compounds which have been shown to be able to inhibit the activation of the type III secretion system (TTSS) and consequently the translocation to the plant cell of virulence factors by the bacterium under investigation.

Possible Applications

  • The invention proposes compounds and methods to combat plant diseases (in particular with reference to kiwi plants)
  • The invention involves the creation of a compound for use as a pesticide
  • It opens the way to possible innovative formulations of pesticides or pesticides to inhibit bacterial virulence

Advantages

  • Reduced environmental impact
  • Use of molecules easily retrivable on the market
  • Impairment of bacterial pathogenicity on plants
  • Limited or absent selection pressure towards the evolution of drug-resistant bacterial populations
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