BACTERIOPHAGES AND THEIR USES FOR TARGETING GD2-EXPRESSING CANCER CELLS
Patent Information
Patent Owners
Università di BolognaPriority Number
Priority Date
Patent Status
License
Keywords
Cancer, Phages
Research Team | Inventors
Loginto view data
Loginto download PDF
Drug Design & Delivery Systems
GD2 gangliosides are widely expressed on the surface of neuroblastoma cells. Neuroblastoma (NB) is one of the most common pediatric neuroendocrine tumors. The present invention pertains to a bacteriophage, or a composition containing it, that includes and/or expresses at least one ligand targeting disialoganglioside (GD2), and its medical or diagnostic uses.
Through the utilization of an engineered filamentous M13 phage vector, there exists the capability to selectively deliver substantial amounts of therapeutic molecules (such as photosensitizers, sonosensitizers, chemotherapeutics, etc.) to GD2+ tumor cells, thereby inducing their cellular demise. This system furnishes compelling evidence of specificity and sensitivity for GD2+ cells while demonstrating a lack of binding to GD2-negative cells.