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Stem-based composite nanomaterial for tissue regeneration

atroscopic surgeryBio3DprinterOsteoarthritisStem cellsTechShareDay-d1w2


Osteoarthritis affects 40 million Europeans with a significant impact on national health of ~ 50.4 billion euros per year. The disease involves cartilage and joint degeneration causing pain and disability. Current surgical methods involve invasive and repeated approaches over time. This invention is a composite material, released by a 3D Bioprinter, which allows tissue regeneration in situ by exploiting external ultrasonic stimulation, without the need for multiple interventions.

Technical features

The invention aims to replace the need for repeated injections for tissue regeneration and / or surgery to replace the entire joint. In fact, the invention is an organic-based composite material released by a 3D printer integrated into an arthroscopic tool. The composite material is inserted only once in the site of interest, and allows the tissue to be regenerated through external stimulation of the intervention site, even at a distance over time without having to intervene surgically every time the need for treatment is evident. Furthermore, a treatment management system has been designed in an intelligent way and integrated with an App for remote monitoring by specialized personnel. This would have a significant impact considering that the need for hospitalization for elderly patients could be avoided or at least reduced over time thanks to remote monitoring.

Possible Applications

  • Minimally invasive surgery;
  • Arthroscopic surgery;
  • Osteoarthritis treatment;
  • Degenerative disease treatment;
  • Stem cell-mediated regenerative treatment.


  • Minimally invasive device;
  • High adherence to therapy;
  • High control of therapy;
  • Remote control of therapy and course;
  • No disturbance in the patient’s daily life;
  • High compatibility with the technological standards of the future, IOT and Machine Learning.