Simultaneous acquisition of images by Spin resonances
The present invention refers to the technological field of equipment and methods of simultaneous imaging through electronic spin resonance (EPR/EPRI, Electron Paramagnetic Resonance and Electron Paramagnetic Resonance Imaging) and nuclear spin resonance (NMR/MRI, Nuclear Magnetic Resonance and Magnetic Resonance Imaging). In particular, it concerns a method and an apparatus for the simultaneous analysis with multimodal technique of the behavior and spatial distribution of the paramagnetic markers (spin probes) present in a sample of biomedical interest.
The study of the behaviour and distribution of the paramagnetic markers indicated in the scientific literature as “spin probes” is currently carried out using two different techniques, respectively called “Overhauser/PEDRI Imaging” (OMRI) and EPRI. OMRI exploits the phenomenon of dynamic nuclear polarization to obtain an increase in nuclear polarization. This acquisition is conditioned by some parameters, such as temperature, the presence of oxygen, etc. … Direct EPRI analysis of spin probes can be performed using continuous (CW) or pulsed (FT) techniques. The latter mode has technical drawbacks that make it difficult to apply. A general purpose of this description is to provide an apparatus that allows to perform simultaneously an EPRI and an MRI analysis, taking advantage of the features and advantages and eliminating the drawbacks of the two modes.
- Nuclear Magnetic Resonance Imaging;
- Electronic Magnetic Resonance Imaging.
- Simultaneous analysis using two modes of magnetic resonance imaging;
- Increased accuracy through optimal use of the acquisition method;
- Ease and effectiveness of use for end users.