Politecnico di Torino - Corso Duca degli Abruzzi, 24 - 10129 Torino, ITALY

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Scintigraphic probe integrated with optical imaging

gamma probehybrid dual probeRadio-guided surgery


The patented device has an innovative detection head that is the result of a combination of two different techniques (e.g. optical methods combined with radioactivity counters). A new generation detector, based on more compact photosensors, is used to develop an innovative intraoperative probe by combining scintigraphic localisation and in situ tissue analysis (e.g. fluorescence or Raman technique). The use of such multisensor probes paves the way for more targeted navigation within the body to more accurately investigate specific tissues for tumours detection and resection.


Technical features

The device has a detection head in which the scintigraphic detectors are circularly arranged on the external part of the circular ring of the detection head. The sensor for optical analysis (fluorescence or Raman technique) is positioned in the centre of the probe. We use a special Raman SORS (Spatially Offset Raman Spectroscopy) technique to analyse deep tissue. Raman SORS is a technique that allows chemical analysis of sub-surface layers of even biological samples and uses the Raman spectroscopic fingerprinting of molecules to allow identification and specific chemical quantification of materials even at depths of several millimetres.
The scintigraphic detectors locate the pathology, defined as the area of greatest uptake, by placing it in the centre of the probe, where it is possible to obtain in situ optical imaging. The device can then identify the presence of structures (micrometastases, microcalcifications, etc.) or define the contours of the lesion (identification of tumour margins) using the Raman SORS technique.


Possible Applications

Medical device for:

  • radioguided surgery;
  • intraoperatory surgery;
  • Gamma probes.


  • optical analysis (in situ) of lymph nodes and tissues to highlight the presence of micro-calcifications;
  • reduced invasiveness per patient thanks to the “in vivo” analysis and subsequent laboratory analysis;
  • fast acquisition time.