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NANOPARTICLES FOR IMAGING AND RADIATION THERAPY

alloy nanoparticlesContrast agentMRI CTnanomedicinananomedicineRadiosensitizer

Introduction

The invention relates to nanoparticles (NPs) comprising a metal alloy and a biocompatible organic stabilizer, for use in the diagnosis and therapy of conditions such as cancer.

Technical features

These alloy NPs possess the necessary characteristics of a contrast agent for diagnostic techniques based on the acquisition of three-dimensional images of the human body, such as magnetic resonance imaging (MRI) and X-ray computed tomography (CT). The alloy NPs can also be employed as a sensitizer for radiotherapy techniques such as radiotherapy by X-rays (XRT) or boron neutron capture (BNCT). In some of the embodiments of the invention, all these characteristics can coexist in the same metal NP, allowing image-guided radiotherapy, where both imaging and/or therapeutic effects can be achieved simultaneously. The composition of the alloy NP can be selected so that they are biocompatibile and degrade spontaneously over time within the body, allowing enhanced NP clearance. The nanoparticles can be synthesized by a one-step, low-cost and environmentally friendly process. Current TRL is 4. Further development will require optimization of the NPs on animal models, investigation of long-term toxicity and clinical trials.

Possible Applications

  • Image-guided radiotherapy;
  • Sensitizers for radiotherapy;
  • Bimodal imaging (MRI/CT).

Advantages

  • Limits the use of multiple contrast agents;
  • Localization of radio-sensitizers by bimodal imaging;
  • Compatible with MRI and CT;
  • Compatible with x-ray radiotherapy and boron neutron capture therapy;
  • Biodegradable;
  • Low-cost and green synthesis, scalable to clinical requirements.