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Multi: multifunctional titanium surfaces

AntibacterialBoneSoft tissuesSurface treatmentsTitanium

Introduction

The proposed inventions cover a serie of surface treatments, suitable for titanium and its alloys, aimed at improving their interaction with biological tissues in biomedical implants. The proposed treatments are focused on specific implant areas in contact with soft or hard tissues and allow to optimize their interaction with the specific biological context. Moreover, they are designed for reduction of the infection risk without the employemnt of antibiotics.

Technical features

Implant zones for soft tissue contact (e.g. dental implant collars): nanogrooves for the imporvement of soft tissue adhesion and cellular orientation. The proposed grooves do not increase bacterial adhesion. The biological performences of the surface can be imporved by the deposition of keratin nanofibres. Finally, an effective antibacetrial action can be obtained by the addition of inorganic ions within  fibres.

Implant zones for hard tissue contact (e.g. bone dental and orthopedic implants): bone integration is supported by a peculiar surface topography (nanoroughness) that can be overlapped to micro-macro roughness from previous manufacturing routes, and chemistry, which induce hydroxyapatite precipitation upon contact with physiological fluids. Surface wettability and protein absorption are increased as well as osteoblast adhesion and differetiation. Nanoroughness does not increase bacterial adhesion and an antibacterial action can be obtained through the addition of an antibacetrial agent in the same process.

Possible Applications

  • Dental implants;
  • Orthopedic implants;
  • Trauma fixation devices;
  • Spinal implants;
  • Prostheses.

Advantages

  • Multifunctional action (topography and chemistry);
  • Multi-step processes: the level of complexity can be chosen depending on the application;
  • Antibacterial action without antibiotics;
  • Rapid processes, easily industrializable;
  • Suitable for conventional sterilization/storage;
  • No coatings, unaltered mechanical resistance and improved corrosion resistance.(bone contact).