Identification of male infertility based on polymorphisms of vitamin D
Couple infertility can affect up to 15% of new couples who wish to become parents. In the context of male causes, the idiopathic one is certainly the most frequent. The invention aims to provide an answer to the diagnosis of idiopathic male infertility.
The availability, access and quality of interventions to address infertility remain a challenge in most countries. The most frequent cause of male infertility is idiopathic (< 40%) that the clinicians can currently diagnose only after the exclusion of other causes by means of a series of complex investigations involving hormonology, microbiology, and genetic laboratories. This technology proposes a method for the qualitative-quantitative identification of single polymorphism in the vitamin D receptor gene, which is predictive of idiopathic testicular damage. This dosage, therefore, appears to be an effective non-invasive method of predicting male idiopathic infertility.The invention provides for the creation of a diagnostic kit to determine the propensity of a male to infertility that can be introduced as part of the diagnostic path of the entire male population that refers to assisted fertilization centers for primary couple infertility.
- Prevention and diagnosis of idiopathic infertility in men.
- Diagnosis of male infertility in assisted reproduction centers.
- Single sampling
- Non-invasive method
- Mono-factorial method on single polymorphism highly predictive of idiopathic testicular damage