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Functionalized Hyaluronic Acid

Aging Wrinkle TreatmentCosmeticDry Eye SyndromePharmaceutic

Introduction

Hyaluronic Acid (HI) is a widespread physiological polymer suffering from in vivo degradation. Infiltration or ocular administration of HI are therefore common strategies to reduce osteoarticular inflammation, ocular dryness and dermal quality degradation. Nonetheless the benefits are limited because the treatments are symptomatic and do not address the problem of HI enzymatic degradation. The modified HI we propose preserves the physical and chemical properties of native HI (lubricant, injectable, a-toxic, hydrating) but is more stable in vivo at enzymatic degradation and is able to regulate the uncontrolled enzymes’ inflammatory activity.

Technical features

The inherent biocompatibility and biodegradability together with the susceptibility to chemical modifications make HI attractive for the development of biomaterials with promising and broad clinical potential. The particular role of natural lubricant and the excellent water-retaining properties make HI a suitable compound for use in ophthalmic products. Linear HI is enzymatically degraded in a short time, also due to ongoing inflammatory states. To slow down this physiological process, often the HI is chemically modified: in these cases we talk about “cross-linked HI”. The greater the cross-linking of the HI, and the greater the time for its complete degradation, but often this stability is accompanied by the alteration of the physical characteristics of the functionalized product. Compared to other functionalized polymers, the patented HI benefits from a long resistance to degradation without altering the physical characteristics of the polymer.

Possible Applications

  • Prevention of corneal damage due to inflammatory states;
  • Ophthalmic products to lubricate the eye;
  • Reduction of osteoarticular inflammation, dry eyes and skin degradation;
  • Interfere with conea desquamation.

Advantages

  • Non-toxic;
  • Stable in vitro with hyaluronidases;
  • Able to inhibit the uncontrolled activation of proteolytic metal-enzymes;
  • Greater resistance to polymer degradation and effectiveness;
  • The hydration / lacrimation is completely comparable with that note obtained with HA (no extra lacrimation).