ELECTROSPUN FIBERS FOR MICROORGANISMS
The invention relates to a process that exploits the use of electrospun fibers for cultivation and increase in productivity of antibiotics as secondary metabolites by bacterial microorganisms belonging to the group of Actinomycetes.
Actinomycetes are bacteria of industrial interest, from which about 70% of the bioactive molecules are obtained. The present invention describes a method for increasing the productivity of antibiotics and other secondary metabolites by these microorganisms by using electrospun fibers as structural supports for their cultivation in both liquid and solid media. By providing hydrophobic supports of adequate size and microstructure, the electrospun fibers create a more favorable microenvironment for growth and development of these microorganisms, and for cellular activities associated with the production of secondary metabolites, compared to the traditional cultivation systems. The efficacy of electrospun polystyrene fibers is demonstrated on the production of actinorhodin and undecylprodigiosin by Streptomyces lividans.
- Antibiotics and other biologically active substances including immunosuppressants and anti-tumor agents;
- Organic acids;
- Amino acids;
- Large scale applicability;