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Analogues and derivatives of dicarboxylic amino acids as antibacterials

AntibioticsEnzyme InhibitorsMultidrug resistancePathogenic bacteriaPhosphinic compounds


This invention is part of the scientific context of combating the multiple resistances developed by many bacteria to antibiotics currently on the market. The invention distorts the concept that antibiotics can only have a certain chemical nature, around which a market has developed that is no longer able to be innovative, and which therefore has only produced molecules that are chemically related to each other.

Technical features

Bacteria, thanks to their genomic plasticity, are able to adapt quickly and often develop resistance to the action of antibiotics, so it is necessary to identify new molecules, which have a different mechanism of action from most antibiotics in use and which are effective. even on bacteria that have now developed multi-resistance. The invention concerns the use of new chemical compounds, which may prove to be interesting antibiotics, in the fight against infections caused by multi-resistant bacteria. The originality of the invention lies in the fact that the compounds in question, derivatives of dicarboxylic amino acids, each penetrate into bacterial cells through different transport mechanisms, thus increasing the range of cell penetration pathways. The compounds can be administered to a patient (human or animal) in pharmaceutical compositions in which they are mixed with suitable solid or liquid pharmaceutically acceptable carriers or excipients suitable at doses capable of improving or treating a series of conditions.

Possible Applications

  • Antibacterials, alone or in combination with other antibiotics to fight infections caused by Gram-positive e Gram-negative bacteria;
  • Formulation of disinfectants of the skin or of the oral cavity, as well as of the external genitals;
  • Antibacterial to be applied on organic or inorganic materials of surfaces, containers, instruments, equipment and medical equipment.


  • These compounds can be substrates or inhibitors of enzymes in the bacterial central metabolism, therefore compromising the cellular viability;
  • These compounds be employed in the treatment to bacterial infections, especially against multi-drug resistant bacteria;
  • These compounds have the ability to enter the bacterial cell through diverse transporters.