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An implantable flexible device for loco-regional sustained drug delivery – μMESH

Combinatorial TherapyMalignanciesRegenerative medicineRegional Drug DeliveryTechShareDay-d3w1Tissue engineering

Introduction

The μMESH is an innovative implantable device, designed for the long-term release of multiple payloads. It is composed by two compartment fused together in a single polymeric membrane. Each compartment is made by a different biocompatible material, allowing the loading and release of both hydrophobic (i.e., chemotherapeutics) and hydrophilic drugs (i.e., biologics, nanoparticles, etc.), and thus exploiting the use of combinatorial approaches. Being also very flexible, the μMESH can perfectly adhere with the tissues in the implantation site, improving its pharmacological action.

Technical features

The implantable flexible device– μMESH – is engineered to realize a long and sustained release of therapeutic molecules up to several months. The μMESH is fabricated employing silicon microchip technologies and polymer chemistry, returning a device with a precise geometry and physico-chemical features. The μMESH appears as a thin PLGA membrane, with a regular network of evenly spaced 20 μm holes, supported by a PVA backing layer. The PLGA membrane carries hydrophobic molecules, such as most chemotherapeutics, while the PVA layer contains hydrophilic molecules, such as nucleic acids, proteins (biologicals) and nanoparticles. Both PLGA and PVA are biocompatible, biodegradable and FDA-approved materials. This tiny membrane deforms and tightly conforms to biological surfaces, as those resulting from surgical resections. The μMESH can also establish an intimate interaction with living cells, key feature for regenerative medicine application.

Possible Applications

  • Treatment of resectable and unresectable tumors developing in the brain, pancreas, abdominal cavity, breast and others;
  • Wound healing;
  • Tissues regeneration and repair.

Advantages

  • Enabling combination therapy via a dual compartment, finely tuning the long-term release of two or more therapeutic molecules;
  • Preventing systemic adverse effects;
  • Modular fabrication strategy, to address different medical application;
  • Biodegradable and approved materials for clinical applications;
  • Enhancing the efficacy of the device through its ability to conform to complex surfaces.