Politecnico di Torino - Corso Duca degli Abruzzi, 24 - 10129 Torino, ITALY

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Advanced Biotech Medicated Dressing in textured fiber

Advanced Medicated DressingDrug Delivery SystemsiRNATextured Fiber MaterialTopical Treatment

Introduction

Severe burns involving face and upper body generally leads to disfigurement, scar contractures and hypertrophic scars, which can lead to severe functional impairment, psychological morbidity, and costly long-term healthcare. The present invention pertains the pharmaceutical/medical field and, in particular, it relates to a delivery platform technology of nucleic acids for preventing hypertrophic scars and treating burn wounds and the like. A textured fiber platform (BIOFIBER) has been developed, which can be used for the controlled and sustained delivery of drugs, for effective wound exudate management and for protecting the wound against mechanical insults and bacterial infections. BIOFIBER is proposed for the local delivery of siRNA to the wound bed.

Technical features

BIOFIBER is a new generation of advanced highly absorbent medicated dressings, which features an innovative textured fiber technology and advanced drug delivery technology for gene therapy. It is composed of a biodegradable and biocompatible membrane based on micro- and nano-fibers obtained by electrospinning, and characterized by specific texture to form a flexible, highly absorbent and conformable dressing. It is soft and comfortable for the patient and conformable to challenging body areas.. BIOFIBER has been proven to efficiently control the delivery of siRNA, to effective manage the wound exudate and to support and promote cell proliferation. In BIOFIBER, siRNA is encapsulated into nanocarrier for preserving its efficacy and limiting degradation when it is exposed to exudate in the wound bed.

Currently the technology is at TRL 3.

Possible Applications

  • Burns hypertrophic scars;
  • Surgery scars;
  • Keloids or any skin imperfections;
  • Any scars resulting from disease, accident, surgeries or skin conditions;
  • Wound healing;
  • Hospital use and burn centers.

Advantages

  • Burns hypertrophic scars;
  • Surgery scars;
  • Keloids or any skin imperfections;
  • Any scars resulting from disease, accident, surgeries or skin conditions;
  • Wound healing;
  • Hospital use and burn centers.